Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models.
J Neuroimmunol
; 323: 87-93, 2018 10 15.
Article
em En
| MEDLINE
| ID: mdl-30196839
ABSTRACT
Maternal infection during pregnancy may increase the risk of offspring neurodevelopmental disorders. The preclinical Polyinosinic-polycytidylic acid (PolyIC) model has become one of the most widely used approaches in maternal immune activation (MIA) research. However, variability in molecular weight may impact the immune activating potential of PolyIC. Nulliparous rats injected with high molecular weight PolyIC exhibit pronounced cytokine response and sickness behavior that was not observed in rats injected low molecular weight PolyIC. Although an essential next step is to extend these studies to pregnant animals, the preliminary results suggest that PolyIC molecular weight is an important experimental design consideration.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Poli I-C
/
Imunidade Celular
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2018
Tipo de documento:
Article