[Digital necrosis revealing cold agglutinin disease: Treatment with rituximab]. / Nécroses digitales révélant une maladie des agglutinines froides : traitement par rituximab.
Ann Dermatol Venereol
; 145(12): 761-764, 2018 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-30197053
ABSTRACT
BACKGROUND:
Digital necrosis is rarer than lower limb necrosis and constitutes a medical or surgical emergency. Etiological evaluation is required. Cold agglutinin disease is a cause of digital necrosis but diagnosis is difficult. PATIENTS ANDMETHODS:
Herein we report the case of a 57-year-old man presenting recent paroxysmal acrosyndrome of the left hand subsequently complicated by digital necrosis following occupational exposure to cold in his work as a forklift driver. After etiological evaluation, a diagnosis of primary cold agglutinin disease was made. Intravenous rituximab and topical treatment resulted in complete healing.DISCUSSION:
Cold agglutinin disease is a rare type of auto-immune hemolytic anemia. Following exposure to cold, paroxysmal cutaneous signs are frequent. The disease may be either primary or secondary with B-cell lymphoproliferative disorder, auto-immune disease or infection. A thorough workup is required. To date, the treatment combining the best positive response rate and good safety is rituximab in weekly perfusions over a 1-month period.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Raynaud
/
Deformidades Adquiridas da Mão
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Dedos
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Rituximab
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Imunossupressores
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Anemia Hemolítica Autoimune
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Isquemia
Tipo de estudo:
Etiology_studies
Limite:
Humans
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Male
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Middle aged
Idioma:
Fr
Revista:
Ann Dermatol Venereol
Ano de publicação:
2018
Tipo de documento:
Article