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In vivo CRISPR editing with no detectable genome-wide off-target mutations.
Akcakaya, Pinar; Bobbin, Maggie L; Guo, Jimmy A; Malagon-Lopez, Jose; Clement, Kendell; Garcia, Sara P; Fellows, Mick D; Porritt, Michelle J; Firth, Mike A; Carreras, Alba; Baccega, Tania; Seeliger, Frank; Bjursell, Mikael; Tsai, Shengdar Q; Nguyen, Nhu T; Nitsch, Roberto; Mayr, Lorenz M; Pinello, Luca; Bohlooly-Y, Mohammad; Aryee, Martin J; Maresca, Marcello; Joung, J Keith.
Afiliação
  • Akcakaya P; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
  • Bobbin ML; Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
  • Guo JA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Malagon-Lopez J; Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • Clement K; Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
  • Garcia SP; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Fellows MD; Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
  • Porritt MJ; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Firth MA; Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • Carreras A; Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
  • Baccega T; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Seeliger F; Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • Bjursell M; Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
  • Tsai SQ; Advanced Medicines Safety, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Nguyen NT; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
  • Nitsch R; Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Mayr LM; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
  • Pinello L; Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Bohlooly-Y M; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
  • Aryee MJ; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Maresca M; Pathology Science, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
  • Joung JK; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Nature ; 561(7723): 416-419, 2018 09.
Article em En | MEDLINE | ID: mdl-30209390
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Especificidade por Substrato / Genoma / Proteínas Associadas a CRISPR / Sistemas CRISPR-Cas / Edição de Genes / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Especificidade por Substrato / Genoma / Proteínas Associadas a CRISPR / Sistemas CRISPR-Cas / Edição de Genes / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article