Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution.
Neuromuscul Disord
; 28(10): 865-867, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30217487
ABSTRACT
Rhabdomyolysis with myoglobinuria is a recognized complication of dystrophinopathies. It can be triggered by infections, exercise or volatile anesthetics. To our knowledge, it has never been reported in boys with Duchenne muscular dystrophy (DMD) after the administration of bisphosphonates. We report two patients with DMD who presented an apparent transient rhabdomyolysis with myoglobinuria after zoledronate administration. Possible mechanisms could involve hypophosphatemia, a known dose-dependent side effect of bisphosphonates, and/or direct myotoxicity of biphosphonates. Physicians and families should be aware of rhabdomyolysis with myoglobinuria as a potential uncommon side effect of bisphosphonates in DMD, in particular of zoledronate.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Distrofia Muscular de Duchenne
/
Conservadores da Densidade Óssea
/
Ácido Zoledrônico
/
Mioglobinúria
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Neuromuscul Disord
Ano de publicação:
2018
Tipo de documento:
Article