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Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design.
Magalhães, Joana; Franko, Nina; Annunziato, Giannamaria; Welch, Martin; Dolan, Stephen K; Bruno, Agostino; Mozzarelli, Andrea; Armao, Stefano; Jirgensons, Aigars; Pieroni, Marco; Costantino, Gabriele; Campanini, Barbara.
Afiliação
  • Magalhães J; a P4T group, Department of Food and Drug , University of Parma , Parma , Italy.
  • Franko N; b Laboratory of Biochemistry and Molecular Biology, Department of Food and Drug , University of Parma , Parma , Italy.
  • Annunziato G; a P4T group, Department of Food and Drug , University of Parma , Parma , Italy.
  • Welch M; c Department of Biochemistry , Cambridge University , Cambridge , United Kingdom.
  • Dolan SK; c Department of Biochemistry , Cambridge University , Cambridge , United Kingdom.
  • Bruno A; d Experimental Therapeutics Program , IFOM - The FIRC Institute for Molecular Oncology Foundation , Milano , Italy.
  • Mozzarelli A; b Laboratory of Biochemistry and Molecular Biology, Department of Food and Drug , University of Parma , Parma , Italy.
  • Armao S; e National Institute of Biostructures and Biosystems , Rome , Italy.
  • Jirgensons A; f Institute of Biophysics, CNR , Pisa , Italy.
  • Pieroni M; g Centro Interdipartimentale "Biopharmanet-tec", Università degli Studi di Parma , Parma , Italy.
  • Costantino G; h Latvian Institute of Organic Synthesis , Riga , Latvia.
  • Campanini B; a P4T group, Department of Food and Drug , University of Parma , Parma , Italy.
J Enzyme Inhib Med Chem ; 33(1): 1444-1452, 2018 Dec.
Article em En | MEDLINE | ID: mdl-30221554
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Cisteína Sintase / Bibliotecas de Moléculas Pequenas Tipo de estudo: Prognostic_studies Idioma: En Revista: J Enzyme Inhib Med Chem Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Cisteína Sintase / Bibliotecas de Moléculas Pequenas Tipo de estudo: Prognostic_studies Idioma: En Revista: J Enzyme Inhib Med Chem Ano de publicação: 2018 Tipo de documento: Article