Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart.

De La Fuente, Sergio; Lambert, Jonathan P; Nichtova, Zuzana; Fernandez Sanz, Celia; Elrod, John W; Sheu, Shey-Shing; Csordás, György

De La Fuente, Sergio; Lambert, Jonathan P; Nichtova, Zuzana; Fernandez Sanz, Celia; Elrod, John W; Sheu, Shey-Shing; Csordás, György.

Afiliação

De La Fuente S; MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lambert JP; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Nichtova Z; MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Fernandez Sanz C; Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Elrod JW; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Sheu SS; Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: shey-shing.sheu@jefferson.edu.
Csordás G; MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: gyorgy.csordas@jefferson.edu.

Cell Rep ; 24(12): 3099-3107.e4, 2018 09 18.

Article em En | MEDLINE | ID: mdl-30231993

Assuntos

Sinalização do Cálcio; Cálcio/metabolismo; Mitocôndrias Cardíacas/metabolismo; Miocárdio/metabolismo; Animais; Linhagem Celular; Masculino; Potencial da Membrana Mitocondrial; Camundongos; Camundongos Endogâmicos C57BL; Ratos; Ratos Sprague-Dawley; Sódio/metabolismo

Palavras-chave

Ca2+ mitochondria; NCLX distribution; calcium signaling; cardiac excitation-energetics coupling; cardiac muscle; mitochondria-sarcoplasmic reticulum contact sites; mitochondrial Ca2+ uniporter distribution

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Sinalização do Cálcio / Mitocôndrias Cardíacas / Miocárdio Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2018 Tipo de documento: Article

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