Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.
J Mol Cell Cardiol
; 18(9): 885-95, 1986 Sep.
Article
em En
| MEDLINE
| ID: mdl-3023644
ABSTRACT
The various subtypes of adrenergic receptors represent distinct structural entities which are coupled in different ways to two major transmembrane signalling systems, the adenylate cyclase and phosphatidyl-inositol pathways. Recent evidence suggests that the functional linkage of both beta and alpha 1-adrenergic receptors to their respective effector systems is regulated by covalent modification of the receptors by phosphorylation-dephosphorylation reactions. Receptor phosphorylation appears to lead to desensitization of the biological response to receptor stimulation. Several kinases including protein kinase A, protein kinase C and a cAMP independent kinase appear to participate in these reactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Proteína Quinase C
/
Receptores Adrenérgicos
Limite:
Animals
Idioma:
En
Revista:
J Mol Cell Cardiol
Ano de publicação:
1986
Tipo de documento:
Article