Stages and transitions in dendrite arbor differentiation.
Neurosci Res
; 138: 70-78, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30243907
ABSTRACT
Neurons connect through dendrite arbors to receive inputs from their appropriate partners. The branching pattern, size, and input distribution in the arbor determine neuron function. Complex nervous system activity depends on creating and wiring a wide diversity of neuron types, each with a characteristic arbor organization. Here we discuss how, by tracking arbor differentiation in vivo, a mature dendrite arbor pattern is derived from the compound outcome of a series of different stages of arbor elaboration. We highlight core stages of elaboration shared between different model systems, and how regulating the transformation between these stages controls the dendrite arbor differentiation process. Finally, we discuss how control over these transformations creates neuron type-specific dendrite arbor morphologies, contributes to nervous system evolution, and is perturbed in disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Plasticidade Neuronal
/
Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neurosci Res
Ano de publicação:
2019
Tipo de documento:
Article