Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.

Fuerst, Rita; Yong Choi, Jun; Knapinska, Anna M; Smith, Lyndsay; Cameron, Michael D; Ruiz, Claudia; Fields, Gregg B; Roush, William R

Fuerst, Rita; Yong Choi, Jun; Knapinska, Anna M; Smith, Lyndsay; Cameron, Michael D; Ruiz, Claudia; Fields, Gregg B; Roush, William R.

Afiliação

Fuerst R; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States; Institute of Organic Chemistry, Graz University of Technology, 8010 Graz, Austria.
Yong Choi J; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States; Department of Chemistry and Biochemistry, Queens College and the Graduate Center of the City University of New York, New York 11367, United States.
Knapinska AM; Department of Chemistry & Biochemistry, Florida Atlantic University, Jupiter, FL 33458, United States.
Smith L; Department of Chemistry & Biochemistry, Florida Atlantic University, Jupiter, FL 33458, United States.
Cameron MD; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States.
Ruiz C; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States.
Fields GB; Department of Chemistry & Biochemistry, Florida Atlantic University, Jupiter, FL 33458, United States.
Roush WR; Department of Chemistry, Scripps Florida, Jupiter, FL 33458, United States. Electronic address: roush@scripps.edu.

Bioorg Med Chem ; 26(18): 4984-4995, 2018 10 01.

Article em En | MEDLINE | ID: mdl-30249495

Assuntos

Metaloproteinase 13 da Matriz/efeitos dos fármacos; Inibidores de Metaloproteinases de Matriz/química; Inibidores de Metaloproteinases de Matriz/farmacologia; Animais; Inibidores das Enzimas do Citocromo P-450/farmacologia; Meia-Vida; Humanos; Concentração Inibidora 50; Cinética; Inibidores de Metaloproteinases de Matriz/farmacocinética; Camundongos; Microssomos Hepáticos/metabolismo; Modelos Animais; Ratos; Solubilidade; Relação Estrutura-Atividade

Palavras-chave

In vitro and in vivo pharmacokinetics; Matrix metalloproteinase 13; Microsomal stability; Permeability; Solubility; Structure-activity relationship; Structure-property relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metaloproteinase 13 da Matriz / Inibidores de Metaloproteinases de Matriz Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2018 Tipo de documento: Article

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