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The same but different: cell intercalation as a driver of tissue deformation and fluidity.
Tetley, Robert J; Mao, Yanlan.
Afiliação
  • Tetley RJ; Medical Research Council Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • Mao Y; Medical Research Council Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK y.mao@ucl.ac.uk.
Article em En | MEDLINE | ID: mdl-30249777
The ability of cells to exchange neighbours, termed intercalation, is a key feature of epithelial tissues. Intercalation is predominantly associated with tissue deformations that drive morphogenesis. More recently, however, intercalation that is not associated with large-scale tissue deformations has been described both during animal development and in mature epithelial tissues. This latter form of intercalation appears to contribute to an emerging phenomenon that we refer to as tissue fluidity-the ability of cells to exchange neighbours without changing the overall dimensions of the tissue. Here, we discuss the contribution of junctional dynamics to intercalation governing both morphogenesis and tissue fluidity. In particular, we focus on the relative roles of junctional contractility and cell-cell adhesion as the driving forces behind intercalation. These two contributors to junctional mechanics can be used to simulate cellular intercalation in mechanical computational models, to test how junctional cell behaviours might regulate tissue fluidity and contribute to the maintenance of tissue integrity and the onset of disease.This article is part of the Theo Murphy meeting issue 'Mechanics of development'.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Drosophila melanogaster / Embrião não Mamífero / Epitélio Limite: Animals Idioma: En Revista: Philos Trans R Soc Lond B Biol Sci Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Drosophila melanogaster / Embrião não Mamífero / Epitélio Limite: Animals Idioma: En Revista: Philos Trans R Soc Lond B Biol Sci Ano de publicação: 2018 Tipo de documento: Article