Cloning and characterisation of the Equilibrative Nucleoside Transporter family of Trypanosoma cruzi: ultra-high affinity and selectivity to survive in the intracellular niche.

Campagnaro, Gustavo D; de Freitas Nascimento, Janaína; Girard, Richard B M; Silber, Ariel M; de Koning, Harry P

Campagnaro, Gustavo D; de Freitas Nascimento, Janaína; Girard, Richard B M; Silber, Ariel M; de Koning, Harry P.

Afiliação

Campagnaro GD; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom. Electronic address: g.campagnaro.1@research.gla.ac.uk.
de Freitas Nascimento J; Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, SP 05508-000, Brazil.
Girard RBM; Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, SP 05508-000, Brazil.
Silber AM; Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, SP 05508-000, Brazil. Electronic address: asilber@usp.br.
de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom. Electronic address: Harry.De-Koning@glasgow.ac.uk.

Biochim Biophys Acta Gen Subj ; 1862(12): 2750-2763, 2018 12.

Article em En | MEDLINE | ID: mdl-30251664

Assuntos

Proteínas de Transporte de Nucleosídeo Equilibrativas/metabolismo; Trypanosoma cruzi/metabolismo; Animais; Clonagem Molecular; Proteínas de Transporte de Nucleosídeo Equilibrativas/genética; Genes de Protozoários; Guanina/metabolismo; Guanosina/metabolismo; Filogenia; Timidina/metabolismo; Trypanosoma brucei brucei/genética; Trypanosoma cruzi/genética

Palavras-chave

Equilibrative Nucleoside Transporter; Heterologous expression; Pyrimidine-specific uptake; Thymidine transporter; Trypanosoma brucei; Trypanosoma cruzi

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma cruzi / Proteínas de Transporte de Nucleosídeo Equilibrativas Limite: Animals Idioma: En Revista: Biochim Biophys Acta Gen Subj Ano de publicação: 2018 Tipo de documento: Article

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