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LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Taraborrelli, Lucia; Peltzer, Nieves; Montinaro, Antonella; Kupka, Sebastian; Rieser, Eva; Hartwig, Torsten; Sarr, Aida; Darding, Maurice; Draber, Peter; Haas, Tobias L; Akarca, Ayse; Marafioti, Teresa; Pasparakis, Manolis; Bertin, John; Gough, Peter J; Bouillet, Philippe; Strasser, Andreas; Leverkus, Martin; Silke, John; Walczak, Henning.
Afiliação
  • Taraborrelli L; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Peltzer N; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Montinaro A; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Kupka S; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Rieser E; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Hartwig T; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Sarr A; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Darding M; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Draber P; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Haas TL; Institute of General Pathology, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.
  • Akarca A; Department of Cellular Pathology, University College London, 21 University Street, London, WC1E 6DE, UK.
  • Marafioti T; Department of Cellular Pathology, University College London, 21 University Street, London, WC1E 6DE, UK.
  • Pasparakis M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Center for Molecular Medicine (CMMC), University of Cologne, D-50931, Cologne, Germany.
  • Bertin J; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA, 19422, USA.
  • Gough PJ; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA, 19422, USA.
  • Bouillet P; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.
  • Strasser A; The Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Leverkus M; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.
  • Silke J; The Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3050, Australia.
  • Walczak H; Department of Dermatology & Allergology, University Hospital of RWTH Aachen University, 52074, Aachen, Germany.
Nat Commun ; 9(1): 3910, 2018 09 25.
Article em En | MEDLINE | ID: mdl-30254289
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Fator de Necrose Tumoral alfa / Ubiquitina-Proteína Ligases / Dermatite / Proteína Ligante Fas / Ligante Indutor de Apoptose Relacionado a TNF Limite: Animals Idioma: En Revista: Nat Commun Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Fator de Necrose Tumoral alfa / Ubiquitina-Proteína Ligases / Dermatite / Proteína Ligante Fas / Ligante Indutor de Apoptose Relacionado a TNF Limite: Animals Idioma: En Revista: Nat Commun Ano de publicação: 2018 Tipo de documento: Article