Therapeutic Effect of Linezolid in Children With Health Care-Associated Meningitis or Ventriculitis.
Clin Pediatr (Phila)
; 57(14): 1672-1676, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30261749
ABSTRACT
We evaluated the efficacy of linezolid treatment in 6 children with health care-associated meningitis or ventriculitis (HCAMV) caused by gram-positive cocci. All children were diagnosed and treated at the Ehime University Hospital between January 2010 and December 2017. Of these, 5 were treated with linezolid as an empirical therapy. In these 5 patients, vancomycin was initially used but was changed to linezolid because of cerebrospinal fluid (CSF) culture positivity (n = 3) and a high minimum inhibitory concentration of vancomycin (n = 2). The most common HCAMV pathogens were methicillin-resistant coagulase-negative staphylococci (n = 3). In 3 patients, vancomycin concentration was low in CSF but reached the target concentration in serum, while linezolid concentration was high in both CSF and serum. HCAMV treatment using antimicrobial agents with poor CSF penetration may increase the likelihood of therapy failure. Linezolid is more susceptible as the first-line treatment for HCAMV compared with vancomycin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Infecção Hospitalar
/
Ventriculite Cerebral
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Linezolida
/
Meningite
/
Antibacterianos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Female
/
Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
Clin Pediatr (Phila)
Ano de publicação:
2018
Tipo de documento:
Article