Rab GTPases take centre stage in understanding Entamoeba histolytica biology.
Small GTPases
; 11(5): 320-333, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-30273093
ABSTRACT
Rab GTPases constitute the largest subgroup in the Ras superfamily of GTPases. It is well established that different Rab GTPases are localized in discrete subcellular localization and regulate the membrane trafficking in nearly all eukaryotic cells. Rab GTPase diversity is often regarded as an expression of vesicular trafficking complexity. The pathogenic amoeba Entamoeba histolytica harbours 91 Rab GTPases which is the highest among the currently available genome sequences from the eukaryotic kingdom. Here, we review the current status of amoebic Rab GTPases diversity, unique biochemical and structural features and summarise their predicted regulators. We discuss how amoebic Rab GTPases are involved in cellular processes such as endocytosis, phagocytosis, and invasion of host cellular components, which are essential for parasite survival and virulence.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas rab de Ligação ao GTP
/
Entamoeba histolytica
Limite:
Animals
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Humans
Idioma:
En
Revista:
Small GTPases
Ano de publicação:
2020
Tipo de documento:
Article