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The Main Determinants of Diabetes Mellitus Vascular Complications: Endothelial Dysfunction and Platelet Hyperaggregation.
Carrizzo, Albino; Izzo, Carmine; Oliveti, Marco; Alfano, Antonia; Virtuoso, Nicola; Capunzo, Mario; Di Pietro, Paola; Calabrese, Mariaconsiglia; De Simone, Eros; Sciarretta, Sebastiano; Frati, Giacomo; Migliarino, Serena; Damato, Antonio; Ambrosio, Mariateresa; De Caro, Francesco; Vecchione, Carmine.
Afiliação
  • Carrizzo A; IRCCS Neuromed, 86077 Pozzilli, IS, Italy. albino.carrizzo@gmail.com.
  • Izzo C; Departement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. carmine.izzo93@gmail.com.
  • Oliveti M; Departement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. olivetimarco@yahoo.it.
  • Alfano A; Heart Department, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. antonia.alfano@sangiovannieruggi.it.
  • Virtuoso N; Department of Cardiovascular Medicine, A.O.U. Federico II, 80131 Naples, Italy. n.virtuoso@hotmail.com.
  • Capunzo M; Departement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. capunzom@virgilio.it.
  • Di Pietro P; Departement of Medicine and Surgery, University of Salerno, 84081 Baronissi, SA, Italy. p.dipietro06@virgilio.it.
  • Calabrese M; Rehabilitation Department, A.O.U."San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. mac.calabrese@virgilio.it.
  • De Simone E; Heart Department, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. eros.desimone@sangiovannieruggi.it.
  • Sciarretta S; IRCCS Neuromed, 86077 Pozzilli, IS, Italy. sebastianosciarretta@yahoo.it.
  • Frati G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00161 Rome, Italy. sebastianosciarretta@yahoo.it.
  • Migliarino S; IRCCS Neuromed, 86077 Pozzilli, IS, Italy. fraticello@inwind.it.
  • Damato A; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00161 Rome, Italy. fraticello@inwind.it.
  • Ambrosio M; Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, 00161 Rome, Italy. smigliarino2018@virgilio.it.
  • De Caro F; IRCCS Neuromed, 86077 Pozzilli, IS, Italy. antonio.damato85@libero.it.
  • Vecchione C; IRCCS Neuromed, 86077 Pozzilli, IS, Italy. mattyambr@gmail.com.
Int J Mol Sci ; 19(10)2018 Sep 28.
Article em En | MEDLINE | ID: mdl-30274207
Diabetes mellitus is a common disease that affects 3⁻5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6⁻8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Doenças Vasculares / Endotélio Vascular / Diabetes Mellitus Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Doenças Vasculares / Endotélio Vascular / Diabetes Mellitus Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2018 Tipo de documento: Article