Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting.
Vaccine
; 36(46): 7048-7053, 2018 11 12.
Article
em En
| MEDLINE
| ID: mdl-30297122
ABSTRACT
BACKGROUND:
Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primary vaccination series in infants. This study was taken up to determine whether higher levels of maternal pertussis antibodies attenuate immune response of infants to DTwP vaccination series given at 6-10-14â¯weeks of age.METHODOLOGY:
A total of 261 pregnant women and their infants from four low-income settlements in Karachi, Pakistan were enrolled in this study. The study endpoints were infant antibody titers for Pertussis toxin (PTx), Filamentous hemagglutinin antigen (FHA), Pertactin (PRN) and Fimbriae type 2/3 (FIM) - from birth through 18â¯weeks of age. Cord blood or pre-vaccine pertussis antibody titers indicate the concentration of maternal antibodies transferred to infants. Linear regression models were used to determine the association between higher maternal antibody titers and infant immune response to DTwP vaccine. Geometric Mean Ratio (GMR) was calculated as the ratio of infant antibody titers at specified time points against the maternal antibody titers at the time of delivery.RESULTS:
At eighteen weeks of age, the adjusted ß regression coefficient for PTx was 0.06 (95% CI -0.49-0.61), FHA 0.02 (95% CI -0.26 -0.29), PRN 0.02 (95%CI -0.38- 0.43), and FIM 0.17 (95%CI -0.21-0.54). Among infants who received at least two doses of DTwP vaccine, higher maternal antibody titers did not have any attenuating effect on infant post-immunization antibody titers against all four pertussis antigens.CONCLUSION:
Maternal pertussis antibodies did not attenuate infant's immune response to pertussis antigens in DTwP primary vaccine given at 6-10-14â¯weeks of age.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacina contra Difteria, Tétano e Coqueluche
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Imunidade Materno-Adquirida
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Anticorpos Antibacterianos
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Adolescent
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Adult
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Female
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Humans
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Infant
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Male
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Newborn
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Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2018
Tipo de documento:
Article