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Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity.
Lam, Sio-Hong; Chen, Po-Hsun; Hung, Hsin-Yi; Hwang, Tsong-Long; Chiang, Chih-Chao; Thang, Tran Dinh; Kuo, Ping-Chung; Wu, Tian-Shung.
Afiliação
  • Lam SH; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. shlam@mail.ncku.edu.tw.
  • Chen PH; Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan. pcckuoo@gmail.com.
  • Hung HY; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10308005@email.ncku.edu.tw.
  • Hwang TL; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
  • Chiang CC; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
  • Thang TD; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
  • Kuo PC; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 338, Taiwan. moonlight0604@hotmail.com.
  • Wu TS; Supervisor board, Taoyuan Chinese Medicine Association, Taoyuan 338, Taiwan. moonlight0604@hotmail.com.
Molecules ; 23(10)2018 Oct 05.
Article em En | MEDLINE | ID: mdl-30301176
Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Elastase Pancreática / Lignanas / Alcaloides Limite: Humans Idioma: En Revista: Molecules Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Elastase Pancreática / Lignanas / Alcaloides Limite: Humans Idioma: En Revista: Molecules Ano de publicação: 2018 Tipo de documento: Article