A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing.

Stotani, Silvia; Gatta, Viviana; Medda, Federico; Padmanaban, Mohan; Karawajczyk, Anna; Tammela, Päivi; Giordanetto, Fabrizio; Tzalis, Dimitrios; Collina, Simona

Stotani, Silvia; Gatta, Viviana; Medda, Federico; Padmanaban, Mohan; Karawajczyk, Anna; Tammela, Päivi; Giordanetto, Fabrizio; Tzalis, Dimitrios; Collina, Simona.

Afiliação

Stotani S; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. silviastotani@hotmail.it.
Gatta V; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. silviastotani@hotmail.it.
Medda F; Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. viviana.gatta@helsinki.fi.
Padmanaban M; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. fmedda@centurionbiopharma.com.
Karawajczyk A; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. mpadmanaban@taros.de.
Tammela P; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. akarawajczyk@gmail.com.
Giordanetto F; Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. paivi.tammela@helsinki.fi.
Tzalis D; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. Fabrizio.Giordanetto@deshawresearch.com.
Collina S; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. dtzalis@taros.de.

Molecules ; 23(10)2018 Oct 06.

Article em En | MEDLINE | ID: mdl-30301207

Assuntos

Antibacterianos/síntese química; Bactérias/efeitos dos fármacos; Pentanos/síntese química; Percepção de Quorum/efeitos dos fármacos; Antibacterianos/química; Antibacterianos/farmacologia; Bactérias/patogenicidade; Humanos; Cetonas; Lactonas/química; Lactonas/farmacologia; Pentanos/química; Pentanos/farmacologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

DPD; DPD-related compounds; antibiotic resistance; quorum sensing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pentanos / Bactérias / Percepção de Quorum / Antibacterianos Limite: Humans Idioma: En Revista: Molecules Ano de publicação: 2018 Tipo de documento: Article

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