Effect of surgical site infection on survival after limb amputation in the curative-intent treatment of canine appendicular osteosarcoma: a Veterinary Society of Surgical Oncology retrospective study.
Vet Surg
; 47(8): E88-E96, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-30303552
ABSTRACT
OBJECTIVE:
To determine the influence of surgical site infection (SSI) on the median disease-free interval (DFI) and median survival time (MST) in dogs after amputation in the curative-intent treatment of appendicular osteosarcoma (OSA). STUDYDESIGN:
Multi-institutional retrospective cohort study. ANIMALS Fifteen dogs with OSA and SSI, and 134 dogs with OSA and no SSI.METHODS:
Medical records were reviewed, and dogs were included if the following criteria were met histologic confirmation of OSA, no evidence of metastasis, ≥1 chemotherapy treatment, and available follow-up data. We used the definition of SSI from the Centers for Disease Control and Prevention. Kaplan-Meier estimates of median DFI and MST for the SSI and non-SSI groups were compared by log-rank test. Univariate and multivariate Cox proportional hazard regression analysis was evaluated for associations with DFI and survival.RESULTS:
The median DFI and MST of all OSA dogs were 236 days (95% CI, 181-283) and 283 days (95% CI 237-355), respectively. The median DFI of dogs with SSI (292 days) did not differ from that of dogs without SSI (224 days, P = .156). The MST of dogs with SSI (292 days) did not differ from that of dogs without SSI (280 days, P = .417). Failure to complete chemotherapy was associated with decreased DFI and survival (P < .001). Adjustments for chemotherapy completion found no effect of SSI on survival.CONCLUSION:
SSI did not influence the survival of dogs with appendicular OSA treated with amputation and curative-intent treatment. CLINICALSIGNIFICANCE:
The extended survival associated with SSI after limb-spare surgery for OSA does not appear to be present after amputation. Interactions between the canine immune system and OSA warrant additional study.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Infecção da Ferida Cirúrgica
/
Neoplasias Ósseas
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Osteossarcoma
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Doenças do Cão
/
Internato e Residência
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
/
Risk_factors_studies
Limite:
Animals
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Vet Surg
Ano de publicação:
2018
Tipo de documento:
Article