Thyroid hormone signaling specifies cone subtypes in human retinal organoids.
Science
; 362(6411)2018 10 12.
Article
em En
| MEDLINE
| ID: mdl-30309916
ABSTRACT
The mechanisms underlying specification of neuronal subtypes within the human nervous system are largely unknown. The blue (S), green (M), and red (L) cones of the retina enable high-acuity daytime and color vision. To determine the mechanism that controls S versus L/M fates, we studied the differentiation of human retinal organoids. Organoids and retinas have similar distributions, expression profiles, and morphologies of cone subtypes. S cones are specified first, followed by L/M cones, and thyroid hormone signaling controls this temporal switch. Dynamic expression of thyroid hormone-degrading and -activating proteins within the retina ensures low signaling early to specify S cones and high signaling late to produce L/M cones. This work establishes organoids as a model for determining mechanisms of human development with promising utility for therapeutics and vision repair.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Hormônios Tireóideos
/
Organoides
/
Células Fotorreceptoras Retinianas Cones
/
Regulação da Expressão Gênica no Desenvolvimento
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2018
Tipo de documento:
Article