Silencing of TRPM8 inhibits aggressive tumor phenotypes and enhances gemcitabine sensitivity in pancreatic cancer.

Liu, JieFeng; Hu, GuoHuang; Gong, YuJing; Yu, QianLe; He, Bin; Li, WangHao; He, ZhiGuo; Hao, WenJie; He, ZiChao; Liu, YiPing

Liu, JieFeng; Hu, GuoHuang; Gong, YuJing; Yu, QianLe; He, Bin; Li, WangHao; He, ZhiGuo; Hao, WenJie; He, ZiChao; Liu, YiPing.

Afiliação

Liu J; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
Hu G; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
Gong Y; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
Yu Q; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
He B; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
Li W; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
He Z; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
Hao W; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
He Z; Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People's Republic of China.
Liu Y; Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410078, People's Republic of China. Electronic address: liuyiping@csu.edu.cn.

Pancreatology ; 18(8): 935-944, 2018 Dec.

Article em En | MEDLINE | ID: mdl-30316690

Assuntos

Antimetabólitos Antineoplásicos/uso terapêutico; Desoxicitidina/análogos & derivados; Inativação Gênica; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/terapia; Canais de Cátion TRPM/genética; Adulto; Idoso; Cálcio/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Terapia Combinada; Desoxicitidina/uso terapêutico; Progressão da Doença; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Proteína 2 Associada à Farmacorresistência Múltipla; Invasividade Neoplásica; Neoplasias Pancreáticas/patologia; Prognóstico; RNA Interferente Pequeno/uso terapêutico; Canais de Cátion TRPM/antagonistas & inibidores; Gencitabina

Palavras-chave

Gemcitabine; Invasion; Pancreatic cancer (PC); Proliferation; Sensitivity; TRPM8

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Inativação Gênica / Desoxicitidina / Canais de Cátion TRPM / Antimetabólitos Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pancreatology Ano de publicação: 2018 Tipo de documento: Article

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