PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.

Chan, Lok Hei; Zhou, Lei; Ng, Kai Yu; Wong, Tin Lok; Lee, Terence K; Sharma, Rakesh; Loong, Jane H; Ching, Yick Pang; Yuan, Yun-Fei; Xie, Dan; Lo, Chung Mau; Man, Kwan; Artegiani, Benedetta; Clevers, Hans; Yan, Helen H; Leung, Suet Yi; Richard, Stéphane; Guan, Xin-Yuan; Huen, Michael S Y; Ma, Stephanie

Chan, Lok Hei; Zhou, Lei; Ng, Kai Yu; Wong, Tin Lok; Lee, Terence K; Sharma, Rakesh; Loong, Jane H; Ching, Yick Pang; Yuan, Yun-Fei; Xie, Dan; Lo, Chung Mau; Man, Kwan; Artegiani, Benedetta; Clevers, Hans; Yan, Helen H; Leung, Suet Yi; Richard, Stéphane; Guan, Xin-Yuan; Huen, Michael S Y; Ma, Stephanie.

Afiliação

Chan LH; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China.
Zhou L; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China.
Ng KY; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China.
Wong TL; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China.
Lee TK; Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
Sharma R; Proteomics & Metabolomics Core Facility, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China.
Loong JH; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China.
Ching YP; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China; State Key Laboratory for Liver Research, University of Hong Kong, Pokfulam, Hong Kong, China.
Yuan YF; State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Centre, Guangzhou, China.
Xie D; State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Centre, Guangzhou, China.
Lo CM; State Key Laboratory for Liver Research, University of Hong Kong, Pokfulam, Hong Kong, China; Department of Surgery, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
Man K; State Key Laboratory for Liver Research, University of Hong Kong, Pokfulam, Hong Kong, China; Department of Surgery, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
Artegiani B; Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Utrecht, the Netherlands.
Clevers H; Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Utrecht, the Netherlands.
Yan HH; Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
Leung SY; Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
Richard S; Lady Davis Institute, Jewish General Hospital, and Departments of Oncology and Medicine, McGill University, Montreal, QC, Canada.
Guan XY; State Key Laboratory for Liver Research, University of Hong Kong, Pokfulam, Hong Kong, China; Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
Huen MSY; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China.
Ma S; School of Biomedical Sciences, University of Hong Kong, Pokfulam, Hong Kong, China; State Key Laboratory for Liver Research, University of Hong Kong, Pokfulam, Hong Kong, China. Electronic address: stefma@hku.hk.

Cell Rep ; 25(3): 690-701.e8, 2018 10 16.

Article em En | MEDLINE | ID: mdl-30332648

Assuntos

Carcinoma Hepatocelular/patologia; Metilação de DNA; Regulação Neoplásica da Expressão Gênica; Células-Tronco Neoplásicas/patologia; Proteínas Nucleares/metabolismo; Proteína-Arginina N-Metiltransferases/metabolismo; Fator 3 Associado a Receptor de TNF/genética; Animais; Apoptose; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Proliferação de Células; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; MAP Quinase Quinase 1/genética; MAP Quinase Quinase 1/metabolismo; Sistema de Sinalização das MAP Quinases; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos NOD; Camundongos Knockout; Camundongos Nus; Camundongos SCID; Células-Tronco Neoplásicas/metabolismo; Proteínas Nucleares/genética; Proteína-Arginina N-Metiltransferases/genética; Proteína-Arginina N-Metiltransferases/fisiologia; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto; Quinases raf/genética; Quinases raf/metabolismo; Proteínas ras/genética; Proteínas ras/metabolismo

Palavras-chave

HCC; arginine methylation; cancer stemness; epigenetics; tumor-initiating cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Células-Tronco Neoplásicas / Proteínas Nucleares / Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Metilação de DNA / Fator 3 Associado a Receptor de TNF Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Cell Rep Ano de publicação: 2018 Tipo de documento: Article

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