In vivo ß-catenin attenuation by the integrin &#945;5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.

Li, Yunfei; Xiao, Yajuan; Lin, Hsuan-Pei; Reichel, Derek; Bae, Younsoo; Lee, Eun Y; Jiang, Yiguo; Huang, Xuefei; Yang, Chengfeng; Wang, Zhishan

In vivo ß-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.

Li, Yunfei; Xiao, Yajuan; Lin, Hsuan-Pei; Reichel, Derek; Bae, Younsoo; Lee, Eun Y; Jiang, Yiguo; Huang, Xuefei; Yang, Chengfeng; Wang, Zhishan.

Afiliação

Li Y; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY 40536, United States.
Xiao Y; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY 40536, United States.
Lin HP; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY 40536, United States.
Reichel D; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, United States.
Bae Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, United States.
Lee EY; Department of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY 40536, United States.
Jiang Y; Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Huang X; Departments of Chemistry and Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, United States.
Yang C; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY 40536, United States. Electronic address: chengfeng.yang@uky.edu.
Wang Z; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY 40536, United States. Electronic address: zhishan.wang@uky.edu.

Biomaterials ; 188: 160-172, 2019 01.

Article em En | MEDLINE | ID: mdl-30352320

Assuntos

Antineoplásicos/administração & dosagem; Compostos Bicíclicos Heterocíclicos com Pontes/administração & dosagem; Integrina alfa5/metabolismo; Nanoconjugados/química; Células-Tronco Neoplásicas/efeitos dos fármacos; Via de Sinalização Wnt/efeitos dos fármacos; Animais; Antineoplásicos/uso terapêutico; Compostos Bicíclicos Heterocíclicos com Pontes/uso terapêutico; Linhagem Celular Tumoral; Sistemas de Liberação de Medicamentos; Humanos; Camundongos Nus; Invasividade Neoplásica/patologia; Invasividade Neoplásica/prevenção & controle; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Oligopeptídeos/química; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/metabolismo; Neoplasias de Mama Triplo Negativas/patologia

Palavras-chave

Cancer stem cell (CSC); Integrin α5 (ITGA5); Lipid-polymer hybrid (LPH) nanoparticle; Metastasis; NCTD; Triple negative breast cancer (TNBC); ß-Catenin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Compostos Bicíclicos Heterocíclicos com Pontes / Integrina alfa5 / Nanoconjugados / Via de Sinalização Wnt / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Biomaterials Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google