Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation.

Kruber, Philip; Angay, Oguzhan; Winkler, Anja; Bösl, Michael R; Kneitz, Susanne; Heinze, Katrin G; Gessler, Manfred

Kruber, Philip; Angay, Oguzhan; Winkler, Anja; Bösl, Michael R; Kneitz, Susanne; Heinze, Katrin G; Gessler, Manfred.

Afiliação

Kruber P; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Wuerzburg University, Wuerzburg, Germany.
Angay O; Rudolf Virchow Center, Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.
Winkler A; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Wuerzburg University, Wuerzburg, Germany.
Bösl MR; Department of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.
Kneitz S; Theodor-Boveri-Institute/Biocenter, Physiological Chemistry, Wuerzburg University, Wuerzburg, Germany.
Heinze KG; Rudolf Virchow Center, Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.
Gessler M; Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Wuerzburg University, Wuerzburg, Germany.

Int J Cancer ; 144(6): 1391-1400, 2019 03 15.

Article em En | MEDLINE | ID: mdl-30367465

Assuntos

Neoplasias Renais/genética; Rim/embriologia; Organogênese/genética; Ribonuclease III/genética; Tumor de Wilms/genética; Animais; Apoptose/genética; Transformação Celular Neoplásica/genética; Modelos Animais de Doenças; Feminino; Técnicas de Inativação de Genes; Humanos; Rim/citologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; MicroRNAs/genética; MicroRNAs/metabolismo; Mutação; Células-Tronco/fisiologia

Palavras-chave

DROSHA; Wilms tumor; kidney development; miRNA; microprocessor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles / 7_ODS3_muertes_prevenibles_nacidos_ninos Base de dados: MEDLINE Assunto principal: Tumor de Wilms / Organogênese / Ribonuclease III / Rim / Neoplasias Renais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Int J Cancer Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google