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TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Zhang, Cun-Jin; Jiang, Meiling; Zhou, Hao; Liu, Weiwei; Wang, Chenhui; Kang, Zizhen; Han, Bing; Zhang, Quanri; Chen, Xing; Xiao, Jianxin; Fisher, Amanda; Kaiser, William J; Murayama, Masanori A; Iwakura, Yoichiro; Gao, Ji; Carman, Julie; Dongre, Ashok; Dubyak, George; Abbott, Derek W; Shi, Fu-Dong; Ransohoff, Richard M; Li, Xiaoxia.
Afiliação
  • Zhang CJ; Medical School of Nanjing University, Nanjing, Jiangsu, China.
  • Jiang M; Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
  • Zhou H; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Liu W; Medical School of Nanjing University, Nanjing, Jiangsu, China.
  • Wang C; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Kang Z; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
  • Han B; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Zhang Q; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Chen X; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Xiao J; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
  • Fisher A; Wuhan Institute of Biotechnology, Wuhan, China.
  • Kaiser WJ; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Murayama MA; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Iwakura Y; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Gao J; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Carman J; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Dongre A; Department of Microbiology and Immunology, Emory Vaccine Center, Atlanta, Georgia, USA.
  • Dubyak G; Department of Microbiology and Immunology, Emory Vaccine Center, Atlanta, Georgia, USA.
  • Abbott DW; Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Shi FD; Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki, Noda, Japan.
  • Ransohoff RM; Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki, Noda, Japan.
  • Li X; Discovery Biology, Bristol-Myers Squibb, Princeton, New Jersey, USA.
J Clin Invest ; 128(12): 5399-5412, 2018 12 03.
Article em En | MEDLINE | ID: mdl-30372424
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Microglia / Encefalomielite Autoimune Experimental / Caspase 8 / Quinases Associadas a Receptores de Interleucina-1 / Esclerose Múltipla Limite: Animals / Female / Humans / Male Idioma: En Revista: J Clin Invest Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Microglia / Encefalomielite Autoimune Experimental / Caspase 8 / Quinases Associadas a Receptores de Interleucina-1 / Esclerose Múltipla Limite: Animals / Female / Humans / Male Idioma: En Revista: J Clin Invest Ano de publicação: 2018 Tipo de documento: Article