Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.

Cheung, Alan C M; Díaz-Santín, Luis Miguel

Cheung, Alan C M; Díaz-Santín, Luis Miguel.

Afiliação

Cheung ACM; a Department of Structural and Molecular Biology , University College London, Institute of Structural and Molecular Biology , London , UK.
Díaz-Santín LM; b Institute of Structural and Molecular Biology, Biological Sciences , Birkbeck College , London , UK.

Transcription ; 10(1): 37-43, 2019 02.

Article em En | MEDLINE | ID: mdl-30375921

RESUMO

SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4, providing important insight into Tra1 function.

Assuntos

Histona Acetiltransferases/fisiologia; Glicoproteínas de Membrana/fisiologia; Modelos Genéticos; Proteínas de Saccharomyces cerevisiae/fisiologia; Histona Acetiltransferases/química; Histona Acetiltransferases/metabolismo; Glicoproteínas de Membrana/química; Glicoproteínas de Membrana/metabolismo; Modelos Moleculares; Proteínas de Saccharomyces cerevisiae/química; Proteínas de Saccharomyces cerevisiae/metabolismo; Transativadores/metabolismo; Transativadores/fisiologia; Ativação Transcricional

Palavras-chave

Chromatin and transcription; Eukaryotic transcription; NuA4; SAGA; Tra1; Transcription factors and co-activators; activator; coactivator; histone acetylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Proteínas de Saccharomyces cerevisiae / Histona Acetiltransferases / Modelos Genéticos Tipo de estudo: Prognostic_studies Idioma: En Revista: Transcription Ano de publicação: 2019 Tipo de documento: Article

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