Innate Immune Influences on the Gut Microbiome: Lessons from Mouse Models.
Trends Immunol
; 39(12): 992-1004, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30377046
ABSTRACT
The gut microbiota is important in health and disease. Whereas the intestinal immune system has evolved to protect the mucosal barrier against pathogens, there is much interest in understanding how it influences the composition and functions of resident microbial communities. Overall, host innate immunity exerts little influence on the microbiota at homeostasis, but increases upon immune activation and the onset of inflammation, as well as in the presence of certain members of the microbiota. However, many experiments have not adequately incorporated study design to detect such immune influences, including using proper control groups, precise sampling and timing, and measures beyond broad-scale descriptions of dysbiosis for microbial analysis. We discuss these and other challenges in the context of current understanding of chronic inflammatory disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Microbioma Gastrointestinal
/
Imunidade Inata
Limite:
Animals
Idioma:
En
Revista:
Trends Immunol
Ano de publicação:
2018
Tipo de documento:
Article