The aryl hydrocarbon receptor-cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly.

Ohashi, Hirofumi; Nishioka, Kazane; Nakajima, Syo; Kim, Sulyi; Suzuki, Ryosuke; Aizaki, Hideki; Fukasawa, Masayoshi; Kamisuki, Shinji; Sugawara, Fumio; Ohtani, Naoko; Muramatsu, Masamichi; Wakita, Takaji; Watashi, Koichi

Ohashi, Hirofumi; Nishioka, Kazane; Nakajima, Syo; Kim, Sulyi; Suzuki, Ryosuke; Aizaki, Hideki; Fukasawa, Masayoshi; Kamisuki, Shinji; Sugawara, Fumio; Ohtani, Naoko; Muramatsu, Masamichi; Wakita, Takaji; Watashi, Koichi.

Afiliação

Ohashi H; From the Department of Virology II and.
Nishioka K; the Tokyo University of Science Graduate School of Science and Technology, Noda 278-8510, Japan, and.
Nakajima S; From the Department of Virology II and.
Kim S; the Tokyo University of Science Graduate School of Science and Technology, Noda 278-8510, Japan, and.
Suzuki R; From the Department of Virology II and.
Aizaki H; the Tokyo University of Science Graduate School of Science and Technology, Noda 278-8510, Japan, and.
Fukasawa M; From the Department of Virology II and.
Kamisuki S; From the Department of Virology II and.
Sugawara F; From the Department of Virology II and.
Ohtani N; the Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Muramatsu M; the Tokyo University of Science Graduate School of Science and Technology, Noda 278-8510, Japan, and.
Wakita T; the Tokyo University of Science Graduate School of Science and Technology, Noda 278-8510, Japan, and.
Watashi K; the Tokyo University of Science Graduate School of Science and Technology, Noda 278-8510, Japan, and.

J Biol Chem ; 293(51): 19559-19571, 2018 12 21.

Article em En | MEDLINE | ID: mdl-30381393

Assuntos

Citocromo P-450 CYP1A1/metabolismo; Hepacivirus/fisiologia; Metabolismo dos Lipídeos; Receptores de Hidrocarboneto Arílico/metabolismo; Montagem de Vírus; Linhagem Celular; Flutamida/farmacologia; Hepacivirus/efeitos dos fármacos; Humanos; Gotículas Lipídicas/efeitos dos fármacos; Gotículas Lipídicas/metabolismo; Metabolismo dos Lipídeos/efeitos dos fármacos; Ligação Proteica; Montagem de Vírus/efeitos dos fármacos

Palavras-chave

CYP1A1; Hepatitis C virus (HCV); aryl hydrocarbon receptor (AhR) (AHR); cytochrome P450; fatty acid metabolism; hepatitis; hepatocyte; lipid droplet; triglyceride; virus assembly

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Receptores de Hidrocarboneto Arílico / Hepacivirus / Montagem de Vírus / Citocromo P-450 CYP1A1 / Metabolismo dos Lipídeos Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article

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