Age-related changes in gingival blood flow parameters measured using laser speckle flowmetry.
Microvasc Res
; 122: 6-12, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30393008
ABSTRACT
Previous studies have suggested a possible relationship between age-related changes to human gingival hemodynamics and periodontal disease. However, firmly establishing this has been difficult because of a lack of suitable tools. Our study investigated whether a non-invasive laser speckle flowgraphy (LSFG)-based 2-dimensional technique could be used to assess maxillary anterior gingival blood flow under resting conditions. In total, 124 healthy male volunteers aged between 22 and 69â¯years were included in the study and delineated into young (Y; 22-37â¯years, nâ¯=â¯45), middle-aged (M; 38-53â¯years, nâ¯=â¯43), and elderly groups (E; 54-69â¯years, nâ¯=â¯36). The differences in gingival hemodynamics were compared among age groups and pulse waveform analysis performed to calculate blood flow indices, mean blur rate (MBR), gingival vascular conductance (MBR/mean blood pressure [MBP]), and three pulse waveform parameters (acceleration time index [ATI], falling rate, and blowout time [BOT]). Although no statistically significant differences were observed in the MBR of the three age groups, vascular conductance (MBR/MBP) was lower in groups M and E compared to group Y and correlated negatively with age. ATI and falling rates were also significantly higher in group E relative to group Y, whereas average BOT was significantly lower. All of the assessed parameters correlated with age. These data suggest that there are age-related decreases in the ability to maintain blood flow in the human maxillary anterior gingiva under resting conditions which may impact the likelihood of periodontal disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Fluxometria por Laser-Doppler
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Microvasos
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Gengiva
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Microcirculação
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Microvasc Res
Ano de publicação:
2019
Tipo de documento:
Article