[Clinical analysis of 42 cases of nasal natural killer/T-cell lymphoma prominently presenting as ocular symptoms].

ABSTRACT

Objective:To investigate the clinical features and prognosis of nasal natural killer/T-cell lymphoma(NKTL) with obvious ocular symptoms.Method:We retrospectively analyzed the clinical data of 42 patients with nasal NKTL who prominently showed eye symptoms and were treated from January 2011 to December 2017.Result:After treatment,the patients received complete remission(CR) in 19 cases and partial remission(PR) in 9 cases. The total effective rate was 66.67%.Median followup time was 39 months and 18 patients died.In this study, there was no correlation between sex and prognosis(P>0.05).Age＞60 years was not related to the prognosis of the patients(P>0.05).The 3-year survival rate of patients treated with radiotherapy and chemotherapy was higher than that of patients treated with radiotherapy or chemotherapy alone(73.3%, 16.7%，P<0.01). The 3-year survival rate of patients with B symptoms was 41.7%, which was not related to prognosis(P>0.05).The prognosis of EBV-DNA positive patients was poor(P<0.01). Twenty-six patients with stage Ⅰ and Ⅱ had a better prognosis(P<0.01). Patients with international prognostic index(IPI) ≤1 had a better prognosis than those with IPI≥2(83.3 %, 37.5%，P<0.01).Conclusion:Nasal NKTL lymphomas with prominent ocular symptoms are difficult to diagnose early and easy to be misdiagnosed. Clinicians should make a definite diagnosis by pathological biopsy and immunohistochemistry as soon as possible, and assist in diagnosis by EBER in situ hybridization if necessary.