Pharmacokinetics and tissue distribution study of bisabolangelone from Angelicae Pubescentis Radix in rat using LC-MS/MS.

Ge, Yuanyuan; Li, Zhen; Zhang, Lu; Li, Jin; He, Jun; Hao, Jia; Gao, Xiu-Mei; Chang, Yan-Xu

Ge, Yuanyuan; Li, Zhen; Zhang, Lu; Li, Jin; He, Jun; Hao, Jia; Gao, Xiu-Mei; Chang, Yan-Xu.

Afiliação

Ge Y; Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Li Z; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhang L; Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Li J; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
He J; Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Hao J; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Gao XM; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Chang YX; Key Laboratory of Formula of Traditional Chinese Medicine (Tianjin University of Traditional Chinese Medicine), Ministry of Education, Tianjin, China.

Biomed Chromatogr ; 33(3): e4433, 2019 Mar.

Article em En | MEDLINE | ID: mdl-30414211

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Medicamentos de Ervas Chinesas/farmacocinética; Sesquiterpenos/farmacocinética; Espectrometria de Massas em Tandem/métodos; Angelica; Animais; Estabilidade de Medicamentos; Feminino; Modelos Lineares; Masculino; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Sesquiterpenos/sangue; Sesquiterpenos/química; Distribuição Tecidual

Palavras-chave

Angelicae Pubescentis Radix; LC-MS/MS; bisabolangelone; tissue distribution

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Medicamentos de Ervas Chinesas / Cromatografia Líquida de Alta Pressão / Espectrometria de Massas em Tandem Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Biomed Chromatogr Ano de publicação: 2019 Tipo de documento: Article

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