Extracellular vesicle-associated miRNAs in ovarian cancer - design of an integrated NGS-based workflow for the identification of blood-based biomarkers for platinum-resistance.

Kuhlmann, Jan Dominik; Chebouti, Issam; Kimmig, Rainer; Buderath, Paul; Reuter, Michael; Puppel, Sven-Holger; Wimberger, Pauline; Kasimir-Bauer, Sabine

Kuhlmann, Jan Dominik; Chebouti, Issam; Kimmig, Rainer; Buderath, Paul; Reuter, Michael; Puppel, Sven-Holger; Wimberger, Pauline; Kasimir-Bauer, Sabine.

Afiliação

Kuhlmann JD; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Chebouti I; National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.
Kimmig R; German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Buderath P; German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Reuter M; Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany.
Puppel SH; German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Wimberger P; Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany.
Kasimir-Bauer S; German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Clin Chem Lab Med ; 57(7): 1053-1062, 2019 06 26.

Article em En | MEDLINE | ID: mdl-30422797

Assuntos

Biomarcadores Tumorais/sangue; Vesículas Extracelulares/metabolismo; MicroRNAs/sangue; Neoplasias Ovarianas/patologia; Adulto; Idoso; Idoso de 80 Anos ou mais; Complexos de Coordenação/química; Complexos de Coordenação/uso terapêutico; Resistencia a Medicamentos Antineoplásicos; Vesículas Extracelulares/genética; Feminino; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Pessoa de Meia-Idade; Neoplasias Ovarianas/tratamento farmacológico; Neoplasias Ovarianas/genética; Projetos Piloto; Platina/química; Intervalo Livre de Progressão; Projetos de Pesquisa; Análise de Sequência de RNA; Fluxo de Trabalho

Palavras-chave

extracellular vesicles; microRNAs; next-generation-sequencing; ovarian cancer; platinum-resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / MicroRNAs / Vesículas Extracelulares Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Clin Chem Lab Med Ano de publicação: 2019 Tipo de documento: Article

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