The leaky lung test: a pilot study using inhaled mannitol to measure airway barrier function in asthma.
J Asthma
; 56(12): 1257-1265, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-30444143
ABSTRACT
Objective:
Airway epithelial barrier dysfunction is emerging as an important feature of asthma pathogenesis, but this is difficult to measure in individual subjects. We aimed to develop a noninvasive way to measure airway permeability in asthma.Methods:
Healthy controls and subjects with mild asthma inhaled dry powder mannitol in a dose-escalating manner on two separate occasions, stopping at 155 mg or 315 mg. Serum mannitol levels were measured at baseline and then 30, 90, and 150 min after mannitol inhalation. Mannitol absorption was compared with measurements of airflow obstruction (FEV1) and airway inflammation (FeNO).Results:
Serum mannitol levels increased in a time- and dose-dependent manner in both healthy control and subjects with asthma. There were no significant differences in mannitol absorption when comparing healthy controls and subjects with asthma. Mannitol absorption did not correlate with markers of airway obstruction or inflammation.Conclusions:
Measuring serum concentrations of mannitol after inhalation challenge can potentially provide insights into airway barrier function in asthma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Volume Expiratório Forçado
/
Antiasmáticos
/
Epitélio
/
Manitol
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Asthma
Ano de publicação:
2019
Tipo de documento:
Article