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YAP/TAZ mechano-transduction as the underlying mechanism of neuronal differentiation induced by reduced graphene oxide.
Catanesi, M; Panella, G; Benedetti, E; Fioravanti, G; Perrozzi, F; Ottaviano, L; Leandro, L Di; Ardini, M; Giansanti, F; d'Angelo, M; Castelli, V; Angelucci, F; Ippoliti, R; Cimini, A.
Afiliação
  • Catanesi M; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Panella G; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Benedetti E; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Fioravanti G; Department of Physical & Chemical Sciences, University of L'Aquila, L'Aquila Italy.
  • Perrozzi F; Department of Physical & Chemical Sciences, University of L'Aquila, L'Aquila Italy.
  • Ottaviano L; Department of Physical & Chemical Sciences, University of L'Aquila, L'Aquila Italy.
  • Leandro LD; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Ardini M; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Giansanti F; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • d'Angelo M; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Castelli V; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Angelucci F; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Ippoliti R; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
  • Cimini A; Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila Italy.
Nanomedicine (Lond) ; 13(24): 3091-3106, 2018 12.
Article em En | MEDLINE | ID: mdl-30451074
AIM: The aim of this work is the dissection of the molecular pathways underlying the differentiation effect of reduced graphene oxide (GO) materials in the absence of differentiation agents. MATERIALS & METHODS: Reduced GO is obtained either by drop casting method and heat-treated or biological reduction by the interaction between GO and wtPrxI. Cells were grown on both materials and the differentiation process studied by immunological and morphological detection. RESULTS & CONCLUSION: The results obtained indicate that both reduction methods of GO can determine the modulation of pathway involved in mechano-transduction and differentiation, by affecting YAP/TAZ localization outside the nuclei and increasing neuronal differentiation markers. This suggests that the mechano-transduction pathways are responsible for the differentiation process.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Fatores de Transcrição / Mecanotransdução Celular / Proteínas Adaptadoras de Transdução de Sinal / Grafite / Neurônios Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Fatores de Transcrição / Mecanotransdução Celular / Proteínas Adaptadoras de Transdução de Sinal / Grafite / Neurônios Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2018 Tipo de documento: Article