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Genomic analyses in African populations identify novel risk loci for cleft palate.
Butali, Azeez; Mossey, Peter A; Adeyemo, Wasiu L; Eshete, Mekonen A; Gowans, Lord J J; Busch, Tamara D; Jain, Deepti; Yu, Wenjie; Huan, Liu; Laurie, Cecelia A; Laurie, Cathy C; Nelson, Sarah; Li, Mary; Sanchez-Lara, Pedro A; Magee, William P; Magee, Kathleen S; Auslander, Allyn; Brindopke, Frederick; Kay, Denise M; Caggana, Michele; Romitti, Paul A; Mills, James L; Audu, Rosemary; Onwuamah, Chika; Oseni, Ganiyu O; Owais, Arwa; James, Olutayo; Olaitan, Peter B; Aregbesola, Babatunde S; Braimah, Ramat O; Oginni, Fadekemi O; Oladele, Ayodeji O; Bello, Saidu A; Rhodes, Jennifer; Shiang, Rita; Donkor, Peter; Obiri-Yeboah, Solomon; Arthur, Fareed Kow Nanse; Twumasi, Peter; Agbenorku, Pius; Plange-Rhule, Gyikua; Oti, Alexander Acheampong; Ogunlewe, Olugbenga M; Oladega, Afisu A; Adekunle, Adegbayi A; Erinoso, Akinwunmi O; Adamson, Olatunbosun O; Elufowoju, Abosede A; Ayelomi, Oluwanifemi I; Hailu, Taiye.
Afiliação
  • Butali A; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USA.
  • Mossey PA; Department of Orthodontics, University of Dundee, Dundee, UK.
  • Adeyemo WL; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Eshete MA; School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.
  • Gowans LJJ; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Busch TD; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USA.
  • Jain D; Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USA.
  • Yu W; Department of Anatomy and Cell Biology, University of Iowa, Iowa, IA, USA.
  • Huan L; State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST, Ministry of Science and Technology) and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
  • Laurie CA; Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USA.
  • Laurie CC; Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USA.
  • Nelson S; Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USA.
  • Li M; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USA.
  • Sanchez-Lara PA; Department of Pediatrics, Cedars-Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
  • Magee WP; Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
  • Magee KS; Operation Smile, 3641 Faculty Boulevard, Virginia Beach, VA, USA.
  • Auslander A; Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
  • Brindopke F; Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
  • Kay DM; Wadsworth Center, New York State Department of Health, Albany, NY, USA.
  • Caggana M; Wadsworth Center, New York State Department of Health, Albany, NY, USA.
  • Romitti PA; Department of Epidemiology, College of Public Health, University of Iowa, Iowa, IA, USA.
  • Mills JL; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, USA.
  • Audu R; Department of Virology, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
  • Onwuamah C; Department of Virology, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
  • Oseni GO; Department of Plastic Surgery, Ladoke Akintola University of Science and Technology, Osogbo, Oyo, Nigeria.
  • Owais A; Department of Pediatric Dentistry, University of Iowa, Iowa, IA, USA.
  • James O; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Olaitan PB; Department of Plastic Surgery, Ladoke Akintola University of Science and Technology, Osogbo, Oyo, Nigeria.
  • Aregbesola BS; Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, Nigeria.
  • Braimah RO; Department of Oral and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
  • Oginni FO; Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, Nigeria.
  • Oladele AO; Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, Nigeria.
  • Bello SA; State House Clinic, Asokoro, Abuja, Nigeria.
  • Rhodes J; Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
  • Shiang R; Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
  • Donkor P; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Obiri-Yeboah S; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Arthur FKN; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Twumasi P; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Agbenorku P; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Plange-Rhule G; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Oti AA; Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana.
  • Ogunlewe OM; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Oladega AA; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Adekunle AA; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Erinoso AO; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Adamson OO; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Elufowoju AA; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Ayelomi OI; Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria.
  • Hailu T; School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.
Hum Mol Genet ; 28(6): 1038-1051, 2019 03 15.
Article em En | MEDLINE | ID: mdl-30452639
ABSTRACT
Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or near genome-wide significance on chromosomes 2 (near CTNNA2) and 19 (near SULT2A1). In situ hybridization of Sult2a1 in mice showed expression of SULT2A1 in mesenchymal cells in palate, palatal rugae and palatal epithelium in the fused palate. The previously reported 8q24 was the most significant locus for CL/P in our study, and we replicated several previously reported loci including PAX7 and VAX1.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Fissura Palatina / Genômica / Locos de Características Quantitativas / População Negra / Genética Populacional Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Hum Mol Genet Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Fissura Palatina / Genômica / Locos de Características Quantitativas / População Negra / Genética Populacional Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Hum Mol Genet Ano de publicação: 2019 Tipo de documento: Article