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Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells.
Manatunga, Danushika C; de Silva, Rohini M; de Silva, K M Nalin; Wijeratne, Dulharie T; Malavige, Gathsaurie Neelika; Williams, Gareth.
Afiliação
  • Manatunga DC; Department of Chemistry, University of Colombo, Colombo, 00300, Sri Lanka.
  • de Silva RM; Department of Chemistry, University of Colombo, Colombo, 00300, Sri Lanka. rohini@chem.cmb.ac.lk.
  • de Silva KMN; Department of Chemistry, University of Colombo, Colombo, 00300, Sri Lanka.
  • Wijeratne DT; Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology & Science Park, Mahenwatte, Pitipana, Homagama, 10206, Sri Lanka.
  • Malavige GN; Centre for Dengue Research, Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, 10250, Sri Lanka.
  • Williams G; Centre for Dengue Research, Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, 10250, Sri Lanka.
Chem Cent J ; 12(1): 119, 2018 Nov 23.
Article em En | MEDLINE | ID: mdl-30470922
Ample attention has been devoted to the construction of anti-cancer drug delivery systems with increased stability, and controlled and targeted delivery, minimizing toxic effects. In this study we have designed a magnetically attractive hydroxyapatite (m-HAP) based alginate polymer bound nanocarrier to perform targeted, controlled and pH sensitive drug release of 6-gingerol, doxorubicin, and their combination, preferably at low pH environments (pH 5.3). They have exhibited higher encapsulation efficiency which is in the range of 97.4-98.9% for both 6-gingerol and doxorubicin molecules whereas the co-loading has accounted for a value of 81.87 ± 0.32%. Cell proliferation assays, fluorescence imaging and flow cytometric analysis, demonstrated the remarkable time and dose responsive anti-proliferative effect of drug loaded nanoparticles on MCF-7 cells and HEpG2 cells compared with their neat counter parts. Also, these systems have exhibited significantly reduced toxic effects on non-targeted, non-cancerous cells in contrast to the excellent ability to selectively kill cancerous cells. This study has suggested that this HAP based system is a versatile carrier capable of loading various drug molecules, ultimately producing a profound anti-proliferative effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Cent J Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Cent J Ano de publicação: 2018 Tipo de documento: Article