A helicase links upstream ORFs and RNA structure.
Curr Genet
; 65(2): 453-456, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-30483885
Upstream open reading frames (uORFs) in 5' UTRs of eukaryotic mRNAs are increasingly recognized as important elements that regulate cellular protein synthesis. Since uORFs can start from non-AUG codons, an enormous number of potential uORF initiation sites exists in 5'UTRs. However, only a subset of these sites is used and it has been unclear how actual start sites are selected. Studies of the DEAD-box helicase Ded1p from S. cerevisiae show that translation of uORFs with non-AUG initiation codons occurs upstream of mRNA structures that emerge with defective Ded1p. The data designate mRNA structure as important determinant for non-AUG initiation sites of uORFs. Ded1p can control this RNA structure and thereby regulate uORF translation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Fases de Leitura Aberta
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DNA Helicases
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Regiões 5' não Traduzidas
Idioma:
En
Revista:
Curr Genet
Ano de publicação:
2019
Tipo de documento:
Article