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A novel GABAA receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo.
Yocum, Gene T; Perez-Zoghbi, Jose F; Danielsson, Jennifer; Kuforiji, Aisha S; Zhang, Yi; Li, Guanguan; Rashid Roni, M S; Kodali, Revathi; Stafford, Douglas C; Arnold, Leggy A; Cook, James M; Emala, Charles W.
Afiliação
  • Yocum GT; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York.
  • Perez-Zoghbi JF; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York.
  • Danielsson J; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York.
  • Kuforiji AS; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York.
  • Zhang Y; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York.
  • Li G; Department of Chemistry and Biochemistry, University of Wisconsin , Milwaukee, Wisconsin.
  • Rashid Roni MS; Department of Chemistry and Biochemistry, University of Wisconsin , Milwaukee, Wisconsin.
  • Kodali R; Department of Chemistry and Biochemistry, University of Wisconsin , Milwaukee, Wisconsin.
  • Stafford DC; Milwaukee Institute for Drug Discovery, University of Wisconsin , Milwaukee, Wisconsin.
  • Arnold LA; Department of Chemistry and Biochemistry, University of Wisconsin , Milwaukee, Wisconsin.
  • Cook JM; Milwaukee Institute for Drug Discovery, University of Wisconsin , Milwaukee, Wisconsin.
  • Emala CW; Department of Chemistry and Biochemistry, University of Wisconsin , Milwaukee, Wisconsin.
Am J Physiol Lung Cell Mol Physiol ; 316(2): L385-L390, 2019 02 01.
Article em En | MEDLINE | ID: mdl-30489155

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Barreira Hematoencefálica / Receptores de GABA-A / GABAérgicos Limite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Barreira Hematoencefálica / Receptores de GABA-A / GABAérgicos Limite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Ano de publicação: 2019 Tipo de documento: Article