Determination of an isonicotinylhydrazide derivative, a novel positive inotropic compound, in mouse plasma by LC-MS/MS and its application to a pharmacokinetics study.

Hui, Renjie; Gao, Yueying; Liu, Jingyi; Liu, Haili; Tang, Chunlei; Feng, Bainian

Hui, Renjie; Gao, Yueying; Liu, Jingyi; Liu, Haili; Tang, Chunlei; Feng, Bainian.

Afiliação

Hui R; School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
Gao Y; School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
Liu J; School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
Liu H; School of Biological, Jiangnan University, Wuxi 214122, China.
Tang C; School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
Feng B; School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China; Alfa Biopharmaceuticals, Inc., Wuxi 214122, China. Electronic address: fengbainian@jiangnan.edu.cn.

J Pharm Biomed Anal ; 165: 12-17, 2019 Feb 20.

Article em En | MEDLINE | ID: mdl-30496986

Assuntos

Cardiotônicos/farmacocinética; Cromatografia Líquida/métodos; Hidrazonas/farmacocinética; Naftóis/farmacocinética; Espectrometria de Massas em Tandem/métodos; Animais; Feminino; Masculino; Camundongos; Camundongos Endogâmicos ICR; Reprodutibilidade dos Testes

Palavras-chave

Isonicotinylhydrazine derivative; LCMS/MS; Mice; Pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiotônicos / Cromatografia Líquida / Espectrometria de Massas em Tandem / Hidrazonas / Naftóis Limite: Animals Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2019 Tipo de documento: Article

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