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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Fanning, Saranna; Haque, Aftabul; Imberdis, Thibaut; Baru, Valeriya; Barrasa, M Inmaculada; Nuber, Silke; Termine, Daniel; Ramalingam, Nagendran; Ho, Gary P H; Noble, Tallie; Sandoe, Jackson; Lou, Yali; Landgraf, Dirk; Freyzon, Yelena; Newby, Gregory; Soldner, Frank; Terry-Kantor, Elizabeth; Kim, Tae-Eun; Hofbauer, Harald F; Becuwe, Michel; Jaenisch, Rudolf; Pincus, David; Clish, Clary B; Walther, Tobias C; Farese, Robert V; Srinivasan, Supriya; Welte, Michael A; Kohlwein, Sepp D; Dettmer, Ulf; Lindquist, Susan; Selkoe, Dennis.
Afiliação
  • Fanning S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Haque A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Imberdis T; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Baru V; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Barrasa MI; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Nuber S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Termine D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Ramalingam N; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Ho GPH; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Noble T; Mira Costa College, 1 Barnard Drive, Oceanside, CA 92056, USA.
  • Sandoe J; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Lou Y; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Landgraf D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Freyzon Y; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Newby G; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, MIT, Cambridge, MA 02139, USA.
  • Soldner F; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Terry-Kantor E; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Kim TE; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Hofbauer HF; Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, 8010 Graz, Austria.
  • Becuwe M; Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.
  • Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, MIT, Cambridge, MA 02139, USA.
  • Pincus D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Walther TC; Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteu
  • Farese RV; Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteu
  • Srinivasan S; Department of Chemical Physiology and The Dorris Neuroscience Center, 1 Barnard Drive, Oceanside, CA 92056, USA; The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Welte MA; Department of Biology, University of Rochester, Rochester, NY 14627, USA.
  • Kohlwein SD; Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, 8010 Graz, Austria.
  • Dettmer U; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: udettmer@bwh.harvard.edu.
  • Lindquist S; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; HHMI, Department of Biology, MIT, Cambridge, MA 02139, USA.
  • Selkoe D; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: dselkoe@bwh.harvard.edu.
Mol Cell ; 73(5): 1001-1014.e8, 2019 03 07.
Article em En | MEDLINE | ID: mdl-30527540
Assuntos
Antiparkinsonianos/farmacologia; Descoberta de Drogas/métodos; Inibidores Enzimáticos/farmacologia; Metabolismo dos Lipídeos/efeitos dos fármacos; Metabolômica/métodos; Neurônios/efeitos dos fármacos; Doença de Parkinson/tratamento farmacológico; Estearoil-CoA Dessaturase/antagonistas & inibidores; alfa-Sinucleína/toxicidade; Animais; Caenorhabditis elegans/efeitos dos fármacos; Caenorhabditis elegans/enzimologia; Caenorhabditis elegans/genética; Linhagem Celular; Córtex Cerebral/efeitos dos fármacos; Córtex Cerebral/enzimologia; Córtex Cerebral/patologia; Diglicerídeos/metabolismo; Modelos Animais de Doenças; Neurônios Dopaminérgicos/efeitos dos fármacos; Neurônios Dopaminérgicos/enzimologia; Neurônios Dopaminérgicos/patologia; Humanos; Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos; Células-Tronco Pluripotentes Induzidas/enzimologia; Células-Tronco Pluripotentes Induzidas/patologia; Gotículas Lipídicas/efeitos dos fármacos; Gotículas Lipídicas/enzimologia; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Terapia de Alvo Molecular; Degeneração Neural; Células-Tronco Neurais/efeitos dos fármacos; Células-Tronco Neurais/enzimologia; Células-Tronco Neurais/patologia; Neurônios/enzimologia; Neurônios/patologia; Ácido Oleico/metabolismo; Doença de Parkinson/enzimologia; Doença de Parkinson/genética; Doença de Parkinson/patologia; Ratos Sprague-Dawley; Saccharomyces cerevisiae/efeitos dos fármacos; Saccharomyces cerevisiae/enzimologia; Saccharomyces cerevisiae/genética; Estearoil-CoA Dessaturase/metabolismo; Triglicerídeos/metabolismo; alfa-Sinucleína/genética
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Estearoil-CoA Dessaturase / Inibidores Enzimáticos / Alfa-Sinucleína / Metabolismo dos Lipídeos / Descoberta de Drogas / Metabolômica / Neurônios / Antiparkinsonianos Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Cell Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Estearoil-CoA Dessaturase / Inibidores Enzimáticos / Alfa-Sinucleína / Metabolismo dos Lipídeos / Descoberta de Drogas / Metabolômica / Neurônios / Antiparkinsonianos Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Cell Ano de publicação: 2019 Tipo de documento: Article