Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats.

Chen, Yan; Cheng, Minhua; Su, Ting; Gao, Tao; Yu, Wenkui

Chen, Yan; Cheng, Minhua; Su, Ting; Gao, Tao; Yu, Wenkui.

Afiliação

Chen Y; Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: chenyan_nju@163.com.
Cheng M; Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: cmhnju@163.com.
Su T; Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: 13347975616@163.com.
Gao T; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China. Electronic address: taog1983@aliyun.com.
Yu W; Department of Intensive Care Unit, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address: yudrnj2@163.com.

Biochem Biophys Res Commun ; 508(3): 811-817, 2019 01 15.

Article em En | MEDLINE | ID: mdl-30528733

Assuntos

Relógios Circadianos/genética; Endotoxemia/metabolismo; Hipotálamo/metabolismo; Músculo Esquelético/metabolismo; Pró-Opiomelanocortina/metabolismo; Sirtuína 1/metabolismo; Fatores de Transcrição ARNTL/genética; Fatores de Transcrição ARNTL/metabolismo; Animais; Proteínas CLOCK/genética; Proteínas CLOCK/metabolismo; Citocinas/metabolismo; Endotoxemia/genética; Expressão Gênica; Luz; Masculino; Proteínas Musculares/metabolismo; Pró-Opiomelanocortina/genética; Ratos; Ratos Sprague-Dawley; Proteínas Ligases SKP Culina F-Box/metabolismo; Sirtuína 1/genética

Palavras-chave

Circadian rhythm; Constant light; Endotoxemia; Muscle wasting; POMC; SIRT1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Opiomelanocortina / Músculo Esquelético / Endotoxemia / Sirtuína 1 / Relógios Circadianos / Hipotálamo Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2019 Tipo de documento: Article

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