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Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance.
Hageman, Tyler; Wei, Hui; Kuehne, Patrick; Fu, Jinmei; Ludwig, Richard; Tao, Li; Leone, Anthony; Zocher, Marcel; Das, Tapan K.
Afiliação
  • Hageman T; Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS, USA.
  • Wei H; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.
  • Kuehne P; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA. hui.wei@bms.com.
  • Fu J; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.
  • Ludwig R; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.
  • Tao L; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.
  • Leone A; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.
  • Zocher M; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.
  • Das TK; Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.
Pharm Res ; 36(1): 24, 2018 Dec 10.
Article em En | MEDLINE | ID: mdl-30536043
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano / Regiões Determinantes de Complementaridade / Deutério / Hidrogênio / Anticorpos Monoclonais Idioma: En Revista: Pharm Res Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano / Regiões Determinantes de Complementaridade / Deutério / Hidrogênio / Anticorpos Monoclonais Idioma: En Revista: Pharm Res Ano de publicação: 2018 Tipo de documento: Article