Prenatal exposure to persistent organic compounds and their association with anogenital distance in infants.
Reprod Biomed Online
; 37(6): 732-740, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30539738
ABSTRACT
RESEARCH QUESTION What is the association between prenatal exposure to persistent organic pollutants, separately and combined, and anogenital distance (in-utero endocrine disruption marker). DESIGN:
A cohort study conducted in Sonora, Mexico. Blood concentrations of polychlorobiphenyls (PCB) 28, 74, 118, 138/158, 153, 170, 180 and the isomers of dichlorodiphenyltrichloroethane (DDT) and its metabolites were determined in women in the third trimester of pregnancy; three variants of anogenital distance were measured on five occasions during the first year of life of their infants 82 girls (402 observations) and 74 boys (356 observations).RESULTS:
Boys had negative and significant associations between anogenital distance/height and the concentrations of PCB 28 (betaâ¯=â¯-â¯0.005;Pâ¯=â¯0.006), PCB 74 (betaâ¯=â¯-â¯0.003;Pâ¯=â¯0.013), and PCB 170 (betaâ¯=â¯-â¯0.005;Pâ¯=â¯0.001) when analysed individually. Negative and significant associations were also found using statistical models applied to mixtures of compounds. The latter associations were sometimes larger in magnitude and significance, suggesting a possible potentiation of the compounds. No associations were observed between anogenital distance and DDT in either sex or with PCB in girls.CONCLUSIONS:
The decreased anogenital distance associated with prenatal exposure to the persistent organic pollutants, observed consistently in different analyses, suggests an under-masculinizing effect of these environmental pollutants in boys.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Bifenilos Policlorados
/
DDT
/
Desenvolvimento Fetal
/
Poluentes Ambientais
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Pregnancy
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Reprod Biomed Online
Ano de publicação:
2018
Tipo de documento:
Article