Comparative toxicogenomics of three insensitive munitions constituents 2,4-dinitroanisole, nitroguanidine and nitrotriazolone in the soil nematode Caenorhabditis elegans.

Gong, Ping; Donohue, Keri B; Mayo, Anne M; Wang, Yuping; Hong, Huixiao; Wilbanks, Mitchell S; Barker, Natalie D; Guan, Xin; Gust, Kurt A

Gong, Ping; Donohue, Keri B; Mayo, Anne M; Wang, Yuping; Hong, Huixiao; Wilbanks, Mitchell S; Barker, Natalie D; Guan, Xin; Gust, Kurt A.

Afiliação

Gong P; Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA. ping.gong@usace.army.mil.
Donohue KB; Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA.
Mayo AM; Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA.
Wang Y; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Hong H; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Wilbanks MS; Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA.
Barker ND; Bennett Aerospace Inc., 1249 Kildaire Farm Road, Cary, NC, 27511, USA.
Guan X; Bennett Aerospace Inc., 1249 Kildaire Farm Road, Cary, NC, 27511, USA.
Gust KA; Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA.

BMC Syst Biol ; 12(Suppl 7): 92, 2018 12 14.

Article em En | MEDLINE | ID: mdl-30547801

Assuntos

Anisóis/toxicidade; Caenorhabditis elegans/efeitos dos fármacos; Caenorhabditis elegans/genética; Guanidinas/toxicidade; Toxicogenética; Triazóis/toxicidade; Animais; Anisóis/análise; Anisóis/química; Guanidinas/análise; Análise de Sequência com Séries de Oligonucleotídeos; Medição de Risco; Transcrição Gênica/efeitos dos fármacos; Transcriptoma/efeitos dos fármacos; Triazóis/análise; Triazóis/química

Palavras-chave

Acute toxicity; Caenorhabditis elegans; Differentially expressed genes; Gene set enrichment analysis (GSEA); Insensitive munitions; Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways; Microarray; Toxicogenomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Caenorhabditis elegans / Toxicogenética / Guanidinas / Anisóis Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: BMC Syst Biol Ano de publicação: 2018 Tipo de documento: Article

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