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Effects of cannabidiol in males and females in two different rat models of depression.
Shbiro, Liat; Hen-Shoval, Danielle; Hazut, Noa; Rapps, Kayla; Dar, Shira; Zalsman, Gil; Mechoulam, Raphael; Weller, Aron; Shoval, Gal.
Afiliação
  • Shbiro L; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
  • Hen-Shoval D; Psychology Department, Bar-Ilan University, Ramat Gan, Israel; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
  • Hazut N; Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
  • Rapps K; Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
  • Dar S; Psychology Department, Bar-Ilan University, Ramat Gan, Israel; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
  • Zalsman G; Geha Mental Health Center, Petah Tiqva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Col
  • Mechoulam R; Institute for Drug Research, Medical Faculty, Hebrew University, Jerusalem 91120, Israel.
  • Weller A; Psychology Department, Bar-Ilan University, Ramat Gan, Israel; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
  • Shoval G; Geha Mental Health Center, Petah Tiqva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: shovgal@tau.ac.il.
Physiol Behav ; 201: 59-63, 2019 03 15.
Article em En | MEDLINE | ID: mdl-30571957
The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 "depressive-like" genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabidiol / Transtorno Depressivo / Antidepressivos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabidiol / Transtorno Depressivo / Antidepressivos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2019 Tipo de documento: Article