Your browser doesn't support javascript.
loading
Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F.
Mikusek, Jiri; Nugent, Jeremy; Lan, Ping; Banwell, Martin G.
Afiliação
  • Mikusek J; Research School of Chemistry, Institute of Advanced Studies , The Australian National University , Canberra , Australian Capital Territory 2601 , Australia.
  • Nugent J; Research School of Chemistry, Institute of Advanced Studies , The Australian National University , Canberra , Australian Capital Territory 2601 , Australia.
  • Lan P; Institute of Advanced and Applied Chemical Synthesis , Jinan University , Zhuhai 519070 , People's Republic of China.
  • Banwell MG; Department of Food Science and Engineering , Jinan University , Guangzhou 510632 , People's Republic of China.
J Nat Prod ; 82(1): 96-100, 2019 01 25.
Article em En | MEDLINE | ID: mdl-30589258
ABSTRACT
A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Alcenos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Alcenos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article