Turning back time with emerging rejuvenation strategies.
Nat Cell Biol
; 21(1): 32-43, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30602763
ABSTRACT
Ageing is associated with the functional decline of all tissues and a striking increase in many diseases. Although ageing has long been considered a one-way street, strategies to delay and potentially even reverse the ageing process have recently been developed. Here, we review four emerging rejuvenation strategies-systemic factors, metabolic manipulations, senescent cell ablation and cellular reprogramming-and discuss their mechanisms of action, cellular targets, potential trade-offs and application to human ageing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rejuvenescimento
/
Envelhecimento
/
Senescência Celular
/
Reprogramação Celular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2019
Tipo de documento:
Article