Comparison of invasive and non-invasive aortic wave intensity and wave power analyses in sheep.
Physiol Meas
; 40(1): 015005, 2019 01 29.
Article
em En
| MEDLINE
| ID: mdl-30625426
ABSTRACT
OBJECTIVE:
Wave intensity (WI) and wave power (WP) analyses are powerful approaches for assessing ventricular-vascular interactions and arterial dynamics using invasive and non-invasive methods. However, in vivo comparison of these methods for large arteries is lacking. This study assessed agreement, correlation and relative changes in wave size in invasive and non-invasive aortic WI/WP analyses, and associated sources of error.APPROACH:
The proximal descending thoracic aorta (DTA) of nine wethers was instrumented with a micromanometer and perivascular transit-time flow probe to measure high-fidelity blood pressure (P) and flow (Q) for invasive WI/WP analyses at baseline and during haemodynamic perturbations produced by cardiac pacing, distal DTA constriction and dobutamine-induced inotropic stimulation. In 212 experimental runs, concurrent echocardiographic DTA diameter and velocity (U) data were acquired for non-invasive WI/WP analyses, with measurement of forward compression wave (FCW), backward compression wave (BCW) and forward decompression wave (FDW) cumulative intensity (CI), cumulative power (CP) and wave-related pressure changes (ΔP). MAINRESULTS:
Although agreement between invasive and non-invasive FCW, BCW and FDW CI/CP measures was variable (bias -84% to +7%), correlation was good (R = 0.66-0.84), with lower bias and higher correlation for ΔP variables and similar relative changes in FCW and BCW CI/ΔP during haemodynamic perturbations. Main error sources were overestimation of invasive U due to assumed fixed vessel diameter, inaccuracies in non-invasive Q, and non-invasive underestimation of peak P/U and Q rates of change.SIGNIFICANCE:
Despite variable agreement, non-invasive CI/CP indices correlate well with invasive measurements, and detect relative changes in major waves induced by haemodynamic perturbations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Processamento de Sinais Assistido por Computador
/
Função Ventricular
Limite:
Animals
Idioma:
En
Revista:
Physiol Meas
Ano de publicação:
2019
Tipo de documento:
Article