Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice.
Bull Exp Biol Med
; 166(3): 326-329, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30627908
ABSTRACT
Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem da Esquiva
/
Envelhecimento
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Ácido Glutâmico
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Antagonistas de Aminoácidos Excitatórios
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Memória
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Anticorpos
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2019
Tipo de documento:
Article