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Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal-Organic Frameworks.
Liang, Weibin; Xu, Huoshu; Carraro, Francesco; Maddigan, Natasha K; Li, Qiaowei; Bell, Stephen G; Huang, David M; Tarzia, Andrew; Solomon, Marcello B; Amenitsch, Heinz; Vaccari, Lisa; Sumby, Christopher J; Falcaro, Paolo; Doonan, Christian J.
Afiliação
  • Liang W; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Xu H; Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials , Fudan University , Shanghai 200433 , P.R. China.
  • Maddigan NK; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Li Q; Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials , Fudan University , Shanghai 200433 , P.R. China.
  • Bell SG; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Huang DM; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Tarzia A; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Solomon MB; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Vaccari L; Elettra-Sincrotrone Trieste S.C.p.A, S.S. 14 Km 163,5 in AREA Science Park , 34149 , Basovizza, Trieste , Italy.
  • Sumby CJ; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Falcaro P; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Doonan CJ; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
J Am Chem Soc ; 141(6): 2348-2355, 2019 02 13.
Article em En | MEDLINE | ID: mdl-30636404
ABSTRACT
Encapsulation of biomacromolecules in metal-organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here, we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enzimas Imobilizadas / Interações Hidrofóbicas e Hidrofílicas / Estruturas Metalorgânicas Idioma: En Revista: J Am Chem Soc Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enzimas Imobilizadas / Interações Hidrofóbicas e Hidrofílicas / Estruturas Metalorgânicas Idioma: En Revista: J Am Chem Soc Ano de publicação: 2019 Tipo de documento: Article